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Following the success of CoBrCa 2015, we are pleased to announce that the 2nd World Congress on Controversies in Breast Cancer (CoBrCa) will be held in Barcelona, Spain, September 8-11, 2016. CoBrCa will continue the tradition of directly addressing the key issues facing clinicians in their daily practice. More topics will be addressed. In addition to the key issues in medical oncology, surgery, radiation oncology and supportive care, CoBrCa will address controversial issues in radiology, pathology and reconstruction, with presentations, debates and discussions. The congress will again provide a forum to effectively debate unresolved clinical and therapeutic dilemmas. We look forward to your participation and contribution in shaping the program and to welcoming you the vibrant and beautiful city of Barcelona.